Stella Grant and Will Newman both have cystic fibrosis. Stella has to stay away from anything and anyone that might pass along an infection and jeopardize the possibility of a lung transplant. Will has an antibiotic-resistant bacteria and just wants to go out and see the world instead of the inside of hospitals. To be safe, they need to stay six feet away from each other, but as Stella and Will start to fall in love, safety measures begin to feel like a punishment and they reexamine the risks they're willing to take to live.