Nancy Drew battles the Abominable Snowman! It happens at a new Bio-Dome facility in River Heights, where Nancy, Bess, and George get swept up in a mystery involving five different world environments encased within giant domes, animals and all. It's founded and funded by famed environmentalist billionaire, Cheri Goale. But before the Bio-Dome officially opens, Sasquatch appears within the Arctic dome creating havoc and endangering the future of the facility. Nancy Drew investigates, but is soon trapped within the dome with the legendary Bigfoot.